For years, immunotherapy has shown limited success in prostate cancer, with six phase 3 checkpoint inhibitor trials failing to demonstrate significant benefits. However, researchers are now studying rare patients who experienced exceptional responses to uncover why some tumors can be eliminated while most remain resistant. Studies suggest that prostate cancer is often an immunologically “cold” tumor, lacking active immune cells needed for checkpoint inhibitors to work. Resear

Abstract Purpose: This study evaluated the efficacy and safety of high-dose vitamin D supplementation (VDS) combined with enuresis alarm (EA) therapy in children with primary monosymptomatic nocturnal enuresis (PMNE). Materials and Methods: A 2-arm randomized clinical trial was conducted at a tertiary center in China between December 2024 and May 2025. Children with PMNE and serum 25-hydroxyvitamin D levels below 30 ng/mL were randomly assigned to receive either 8 weeks of VD

The Bladder Cancer Advocacy Network (BCAN) Bladder Cancer Think Tank 2026 hosted the BCAN-Funded Investigator Speakers Session. Dr. Aditi Gupta delved into Identifying Biomarkers of Response and Mechanisms of Resistance to Enfortumab Vedotin with and without Pembrolizumab in Metastatic Urothelial Cancer. Dr. Gupta began by highlighting the remarkable evolution of systemic therapy for metastatic urothelial carcinoma over the last decade. Following decades dominated by platinum

Herbal remedies are widely used by men with lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). Although some plant-based therapies may provide symptom relief, the quality of evidence remains inconsistent, and they are generally less effective than standard pharmacological treatments. Key Herbal Remedies: Saw palmetto: The most studied herbal treatment, but clinical trials have reported conflicting results. Variations in extraction methods and pr

Prostate cancer remains one of the most common cancers affecting men worldwide. Understanding the available treatment options is crucial for managing this condition effectively. Over the years, medical advancements have introduced a variety of therapies that target prostate cancer at different stages. In this article, I will walk you through the most effective advanced prostate cancer therapies, helping you make informed decisions or support those facing this diagnosis. Under

U.S. Food and Drug Administration (FDA) approved the oral antibiotic Utebzi (tebipenem pivoxil) for complicated urinary tract infections (cUTIs), developed by GSK and Spero Therapeutics. It is the first oral carbapenem antibiotic approved in the United States, targeting multidrug-resistant infections that previously required intravenous carbapenems. About three million cUTI cases occur annually in the United States, with roughly one-third experiencing treatment failure due to

A recent study presented at the American Urological Association meeting showed encouraging long-term results for men with benign prostatic hyperplasia (BPH) and bothersome lower urinary tract symptoms (LUTS) treated with the Urocross Expander System. This temporary device is inserted into the prostate through the urethra and remains in place for six months before being removed during a standard cystoscopy. In the Expander-2 trial, involving 240 men aged 45 years and older, pa

Abstract The wide-ranging and demanding role of community nurses is widely recognised. They need to be able to assess and manage a multitude of medical symptoms, general health issues and social factors. As a result, it is essential to have an expansive knowledge base as a starting point. However, the challenge of working in the community, often alone, also means needing a high level of expertise to tackle some challenging and demanding situations. It is essential to recognis

Abstract Purpose: This study evaluated the clinical impact of escalating tamsulosin dosage from 0.2 to 0.4 mg in men with benign prostatic hyperplasia (BPH) who exhibited inadequate responses to the lower dose. Materials and methods: A retrospective review was performed on 57 patients treated at Seoul National University Bundang Hospital in 2022. Uroflowmetry parameters, International Prostate Symptom Score (IPSS), and postvoid residual volume (PVR) were compared before and a

Urinary tract infections (UTIs) are among the most common infections affecting adults over 65 years of age and are linked to significant health complications. Diagnosing UTIs in older adults can be difficult because symptoms are often atypical and may overlap with other conditions. Many elderly patients experience bladder emptying problems, constipation, pelvic organ prolapse, or catheter use, all of which increase infection risk. In addition, asymptomatic bacteriuria — bacte

Prostate cancer remains one of the most common cancers affecting men worldwide. Over the years, medical science has made significant strides in developing advanced prostate cancer therapies. These treatments aim to improve survival rates, reduce side effects, and enhance quality of life. In this post, I will walk you through some of the latest and most promising options available today. Understanding Advanced Prostate Cancer Therapies Advanced prostate cancer therapies refer

Advanced prostate cancer treatments can affect cognitive function, and new findings suggest that one commonly used medication may have a smaller impact on mental performance than another. A phase II clinical trial presented at the American Society of Clinical Oncology (ASCO) meeting compared two androgen receptor pathway inhibitors: darolutamide and enzalutamide. Researchers found that patients treated with darolutamide experienced significantly less cognitive decline over 24

Spinal cord injury (SCI) can significantly affect bladder and bowel control, making incontinence one of the most common long-term complications. This occurs because the spinal cord is responsible for carrying signals between the brain and the bladder and bowel. When this communication pathway is disrupted, the body can no longer properly regulate storage and release functions, leading to a loss of voluntary control. The type of incontinence depends on the level and severity o

Overactive bladder (OAB) is a common condition that affects many men. It causes sudden urges to urinate, frequent trips to the bathroom, and sometimes leakage. Managing these symptoms can be challenging. Fortunately, mirabegron bladder treatment offers a promising solution. This medication works differently from traditional options and can improve quality of life for those dealing with OAB. Understanding Mirabegron Bladder Treatment Mirabegron is a medication designed to rela

At the European Association of Urology annual congress, new findings from the POISE-3 trial showed that tranexamic acid (TXA) can significantly reduce major bleeding in patients undergoing urologic surgery. In a subgroup of over 1,100 patients, major bleeding occurred in 6.1% of those receiving TXA compared to 9.5% in the placebo group, representing a meaningful risk reduction. However, there were no significant differences in broader 30-day efficacy or safety outcomes, inclu

A new study comparing a non-invasive ultrasound treatment for prostate cancer with standard robotic prostate removal shows encouraging early results for the ultrasound approach. The technique, called MRI-guided transurethral ultrasound ablation (TULSA), uses targeted thermal ultrasound under real-time MRI control to destroy prostate tissue while aiming to preserve urinary and sexual function. After six months, patients treated with TULSA had better outcomes in key quality-of-

A new rapid test for urinary tract infections (UTIs) developed by researchers at the University of Reading and University of Southampton could significantly improve how quickly patients receive the right antibiotic treatment. The test, called rapid microcapillary direct-from-urine antibiotic susceptibility testing (RMD AST), uses a simple “dip and test” method to analyze urine samples and determine antibiotic effectiveness in under six hours. This is a major improvement compa

After a spinal cord injury (SCI), many men develop neurogenic detrusor overactivity (NDO)—a condition where the bladder contracts involuntarily while filling. This happens because the brain can no longer properly control bladder signals. Over time, this can lead to leakage, high bladder pressure, and even kidney damage if not managed. It’s important to distinguish NDO from detrusor-sphincter dyssynergia (DSD). NDO is a storage problem (bladder squeezes too early), while DSD i

Prostate cancer is one of the most common cancers affecting men worldwide. Understanding the available treatment options is crucial for managing this condition effectively. Over the years, medical advancements have provided a variety of approaches to treat prostate cancer, tailored to the stage and aggressiveness of the disease. In this article, I will walk you through the most effective cancer treatment options for prostate cancer, helping you make informed decisions or supp

Prostate cancer remains one of the most common cancers affecting men worldwide. Advances in medical science have transformed how we approach this disease. Today, modern prostate cancer solutions offer hope through more precise, effective, and less invasive treatments. Understanding these options can empower you to make informed decisions about care. Exploring Modern Prostate Cancer Solutions Modern prostate cancer solutions focus on targeting the disease while minimizing side