Guideline of guidelines: management of small testicular masses

Abstract

Objective: To compare and summarise the most up to date international guidelines and major recommendations for the management of small testicular masses (STMs).

Methods: A systematic search was conducted in PubMed, EMBASE, Scopus, Google Scholar, and the Cochrane Library up to 1 November 2024. The latest editions of five international guidelines were included in the review: the European Association of Urology 2025; the National Comprehensive Cancer Network 2024; the American Urological Association 2023; the Canadian Urological Association 2022; and the European Society for Medical Oncology 2018. The Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool was applied by two authors (M.T. and G.F.) to assess the quality of these guidelines.

Results: Emerging evidence supports testis-sparing surgery (TSS) as a viable option for managing STMs, showing acceptable oncological outcomes and preservation of gonadal function in select patients. The shared indications for TSS include indeterminate STMs identified on ultrasonography with negative tumour markers, particularly in the case of a solitary testis or of bilateral tumours. Where intra-operative frozen section analysis is available, and confirms a benign lesion, a radical orchidectomy could be avoided.

Conclusion: Consensus across guidelines favours TSS in suitable cases, balancing oncological control with functional outcomes and informed patient decisions.

Tozzi M, Fallara G, Ferro M, Chierigo F, Bianchi R, Alnajjar HM, Pang KH, Muneer A. Guideline of guidelines: management of small testicular masses. BJU Int. 2025 Dec 24. doi: 10.1111/bju.70131. Epub ahead of print. PMID: 41437827.