Purpose: We report the duration of response to UGN-102 treatment in patients with recurrent low-grade intermediate-risk nonmuscle-invasive bladder cancer (LG-IR-NMIBC) 24 months after achieving complete response (CR). Materials and Methods: ENVISION is an ongoing, multinational, single-arm, phase 3 study in patients with biopsy-proven recurrent LG-IR-NMIBC. Patients received 6 once-weekly intravesical instillations of UGN-102. Patients underwent cystoscopy, urine cytology tes

ABSTRACT Objective To define mild, moderate and severe symptom categories of the neurogenic bladder symptom score (NBSS) and NBSS-short form (SF), and to calculate the minimal clinically important difference (MCID) of the NBSS-SF. Methods We used existing datasets from the original NBSS validation study (n = 230 patients with spinal cord injury (SCI), multiple sclerosis, and spina bifida), and a large cross-sectional study of people with SCI (n = 1479) who completed the NBSS.

Abstract Introduction Differences in how Medicare advantage prescription drug plans (MA-PDs) and stand-alone prescription drug plans (PDPs) are financed may contribute to fewer coverage options for traditional Medicare beneficiaries. The Inflation Reduction Act (IRA) capped annual out-of-pocket spending and reduced government reinsurance, thereby placing more cost responsibility on plans and manufacturers and potentially further limiting coverage. Methods This study draws on

ABSTRACT Between 1994 and 2019, the number of treatments designated as ‘reasonable and necessary’ (R&N) for the treatment of an illness that had ever been developed increased from 1210 to 2845. We investigate the effect of R&N treatment growth on the mortality of Americans during the period 1999–2019. We employ a difference-in-differences (disease by year) research design: we measure attributes (the number and mean vintage) of the R&N treatments for a disease that had ever be

Abstract Microplastics (MPs), ubiquitous environmental pollutants, can enter the human body and exacerbate health risks. Polyvinyl chloride MPs (PVC-MPs) are emerging contaminants of particular concern due to direct clinical exposure pathway. However, the role of PVC-MPs in pathogenic bacterial infections remains poorly understood. Here, we investigate the role of PVC-MPs for the pathogenicity of uropathogenic Escherichia coli (UPEC), the primary causative agent of urinary tr

Abstract Purpose: Neurogenic bladder significantly impacts individuals after spinal cord injury. We hypothesized that there would be differences in bladder related symptoms and quality of life for 4 common bladder management methods. Materials and methods: In this prospective observational study we measured neurogenic bladder related quality of life after spinal cord injury. Study eligibility included age 18 years or greater and acquired spinal cord injury. Bladder management

Abstract Introduction: Urodynamic study (UDS) is a valuable diagnostic test in urological practice. Due to the nature of the test, patients may experience emotional and physical discomfort. Mixed information exists on the degree of emotional and physical discomfort and their association with age, sex, body mass index, prior explanation, use of clean intermittent catheterization (CIC), and presence of a neurogenic bladder. Methods: Over a period of 7 months, all patients under

Abstract Introduction: Recurrent benign prostatic obstruction (BPO) is a recognized complication following surgery. While Holmium laser enucleation of prostate (HoLEP) has been shown to be safe and effective as a salvage option after single procedure, outcomes in patients with multiple prior interventions remain poorly defined. This study aimed to evaluate the outcomes of HoLEP in patients with multiple prior BPO surgeries compared with surgery-naïve individuals. Methods: We

Abstract Background Minimally invasive surgical therapies for benign prostatic hyperplasia (BPH) are increasingly utilized but may have limited long-term durability, leading some patients to require re-treatment. Holmium laser enucleation of the prostate (HoLEP) is a size-independent option, but outcomes after prior BPH intervention remain incompletely characterized. We compared perioperative, postoperative, and functional outcomes of HoLEP in re-treatment versus treatment-na

Abstract Introduction: Urinary incontinence (UI)-including stress (SUI), urge (UUI), and mixed (MUI) subtypes-is associated with obesity, and weight loss is commonly recommended for intervention. However, the comparative effects of intentionality and weight loss strategies on UI severity remain poorly defined. Material and methods: We analyzed 16,331 adults from the 2001-2020 NHANES cohorts who self-reported 1-year weight loss and completed the UI questionnaire. Our use of a

Abstract Importance Tamsulosin is the most common treatment for lower urinary tract symptoms (LUTS) attributed to benign prostatic hyperplasia (BPH). The ability of N-of-1 deprescribing trials to identify who may benefit from discontinuing chronic tamsulosin therapy is unknown. Objective To determine if N-of-1 deprescribing trials can identify older men who are receiving minimal benefit from tamsulosin therapy for LUTS. Design, Setting, and Participants Double-blind, plac

Abstract Background: Neurogenic bowel dysfunction is a frequent but often underrecognized problem in patients with multiple sclerosis (MS) and may contribute to disability and reduced quality of life. Objective: The aim of this study was to determine the prevalence and severity of bowel dysfunction in patients with MS using the validated Neurogenic Bowel Dysfunction (NBD) score and to evaluate its associations with urinary dysfunction, anxiety, depression, fatigue, cognitive

Abstract Background and Objectives: Primary central nervous system (CNS) demyelinating disorders such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and seronegative longitudinally extensive transverse myelitis (LETM) frequently affect the autonomic nervous system (ANS). Comprehensive data across genitourinary, sudomotor, gastrointestinal, and sexual domains remain limited, e

Abstract Background PSA is not recommended for screening by The UK National Screening Committee due to risks of over-diagnosis and over-treatment. However, men in England aged 50+can request a PSA test from their GP. Aimes To investigate the association between PSA and cancer mortality and estimate the absolute and relative risk of prostate cancer deaths. Design & setting Nested case–control study using the Clinical Practice Research Datalink (CPRD) GOLD database. Method Cas

Abstract Radical prostatectomy (RP) is a highly effective treatment for localized prostate cancer; unfortunately, post-prostatectomy urinary incontinence (UI) remains a prevalent and distressing complication, significantly diminishing patients’ quality of life. Current therapeutic options often provide incomplete continence restoration and may lead to substantial morbidity. This review examines the rapidly advancing field of regenerative medicine, specifically focusing on ste

Abstract Purpose/Objective(s) Patients with localized prostate cancer have several treatment options including external beam radiotherapy with either photons or protons. Proton beam therapy (PBT) has certain dosimetric advantages with the potential to reduce treatment-associated morbidity and improve oncologic outcomes, but it is generally more resource intensive than intensity modulated radiation therapy (IMRT). To address the hypothesis that PBT results in improved patient-

Abstract Background and objectives: Urinary incontinence (UI) has not been examined in relation to perceptions of age discrimination (ageism). This study examined whether UI, absorbent product use, and confidence gained from absorbent product use are associated with ageism in later adulthood. Research design and methods: Cross-sectional data were collected from 680 community-dwelling female and male participants. Participants were aged 55-73 years; 62% were women. In 2023-202

Abstract Lower urinary tract dysfunction presents with a wide range of bothersome urinary symptoms, which are common in both men and women, with incidence and prevalence increasing with age. Individuals with lower urinary tract symptoms (LUTS) suffer from the chronicity of their symptoms, have a reduced quality of life, and experience high morbidity with associated medical conditions. Various treatment options exist, but many patients do not find satisfactory or lasting relie

Abstract Background: Incontinence-associated dermatitis is prevalent in long-term care facilities and homecare settings among adults who are incontinent of urine and/or faeces. Strategies to protect skin integrity are needed. This study aimed to co-design and test the feasibility of a training manual and care guidance (Incontinence-Associated Dermatitis Manual) to prevent and treat incontinence-associated dermatitis in long-term care facilities and homecare settings. Methods:

Abstract Aims: Nocturnal enuresis (NE) and daytime urinary incontinence (DUI) are often associated with neurodevelopmental disorders (NDs). Among NDs, children with incontinence have a higher rate of developmental coordination disorder (DCD). It is not known if the associated deficits of neuromotor skills persist over time or if they are associated with treatment outcome. Therefore, the aim of the study was to examine the neuromotor skills in children with incontinence prospe