Complicated Urinary Tract Infections (cUTI): Clinical Guidelines for Treatment and Management

IDSA has released the first IDSA guidelines on management and treatment of complicated urinary tract infections (cUTIs). These guidelines provide practical advice for clinicians who manage patients with cUTIs in inpatient and outpatient settings. These guidelines expand the scope of prior UTI guidelines to address complicated UTI, provide a clinically-relevant classification of uncomplicated and complicated UTI, guide the empiric choice of antibiotics for complicated UTI through a step-wise process, offer a recommendation for the timing of IV to oral switch, and address duration of therapy. The panel’s recommendations are based upon evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.

Trautner, B. W., Cortes-Penfield, N. W., Gupta, K., Hirsch, E. B., Horstman, M., Moran, G. J., Colgan, R., O’Horo, J. C., Ashraf, M. S., Connolly, S., Drekonja, D. M., Grigoryan, L., Huttner, A., Lazenby, G., Nicolle, L., Schaeffer, A., Yawetz, S., & Lavergne, V. (2025, July 17). Complicated urinary tract infections (cUTI): Clinical guidelines for treatment and management. [PDF].