Botulinumtoxin for bladder disorders

Abstract

An overactive neurogenic detrusor and an non-neurogenic overactive bladder both exhibit symptoms such as urgency and frequency, both with and without urinary incontinence, and are often accompanied by nocturia. OnabotulinumtoxinA-Detrusorinjection has become well established as a second line therapy in cases where anticholinergic medication has failed. The procedure can be performed under general or local anesthesia, in both in- and outpatient settings. The side effects of the procedure are primarily urinary tract infections and - especially in neurogenic bladder patients - urinary retention. This article focuses on the approved indications and summarizes the current scientific data.

Schulte-Baukloh H, Bauer R, Jost W, Wissel J, van Ophoven A. Botulinumtoxin for bladder disorders. Fortschr Neurol Psychiatr. 2019 Feb;87(1):23-30. German. doi: 10.1055/a-0599-0697. Epub 2018 Dec 3. PMID: 30508871.