Abstract Introduction: Overactive bladder (OAB) is defined as urinary urgency, usually accompanied by increased daytime frequency and/or nocturia, with urgency urinary incontinence (OAB-wet) or without (OAB-dry), in the absence of urinary tract infection or other detectable disease. The key symptom of OAB, urinary urgency, is defined as a complaint of sudden, compelling desire to pass urine which is difficult to defer. However, patients report a range of individual experience

Abstract Background: Falls among older adults remain a major global health concern, often leading to injury, disability, and loss of independence. Physical therapists are key stakeholders in fall prevention, yet their knowledge, attitudes, and practices remain underexplored in Saudi Arabia. Objectives: This study aimed to assess physical therapists' knowledge, attitudes, and confidence regarding fall prevention strategies for adults aged 65 and above and to identify factors i

The Importance of Diverse Clinical Trials This study examines how the underrepresentation of vulnerable patients in clinical trials may lead to underestimated risks of adverse drug effects, particularly regarding cancer medications. Using data from the Surveillance, Epidemiology, and End Results (SEER) Program linked to Medicare claims, researchers analyzed the relationship between trial participation and drug-induced serious adverse events (SAEs). Increased Hospitalization R

Abstract Purpose Active surveillance (AS) is a standard management strategy for low-risk prostate cancer (PCa), but a significant proportion of patients ultimately experience disease progression. Metformin, a commonly prescribed antidiabetic agent, has demonstrated antitumor activity in preclinical studies and observational data, prompting investigation into its potential to delay PCa progression. Patients and Methods The Metformin Active Surveillance Trial (MAST) was a multi

Abstract The diagnostic workflow for prostate cancer detection has evolved substantially with advances in imaging technologies and biopsy techniques. Currently, MRI is the standard modality for prostate imaging in cancer detection. However, the rising incidence of prostate cancer and the limited accessibility and high cost of MRI created a growing need for more cost- and time-effective alternative imaging modalities. Micro-ultrasound (microUS), which enables prostatic ductal

ABSTRACT Aims Recurrent urinary tract infections are a common medical problem and current guidelines recommend both antibiotic and non-antibiotic preventative treatments. However, for a significant proportion of patients with this condition these second-line treatments are not effective. As a result, there has been recent focus on more targeted treatment such as intravesical instillations and bladder fulguration procedures. We aim to report discussions regarding these targete

INTRODUCTION: Urinary incontinence in men after endoscopic enucleation of benign prostate hyperplasia (BPH) can reach 55% and significantly impairing the quality of life and social rehabilitation of patients. A large number of individual patient parameters and features of surgical treatment are considered as potential risk factors. At the same time, the influence of urodynamic factors, including the external urethral sphincter function at the preoperative stage, fades into t

Abstract Context Concerns about potential prostate-related complications associated with testosterone replacement therapy (TRT) often lead hypogonadal men to remain untreated. Methods This large-scale retrospective cohort study aimed to address these concerns by analyzing Medicare enrollment and claims data (Parts A/B/C/D) from 2007 to 2020 for men aged ≥65 with diagnosed primary or secondary hypogonadism. Cox regression analysis and 1:1 propensity score matching, both strati

Abstract Background: Centralized locations in the electronic health record (EHR) improve access to advance care planning (ACP) information; however, the prevalence of documentation errors in these locations is unknown. Methods: In this cross-sectional study, we included primary care patients aged ≥65 years or ≥18 years with a serious illness. We verified errors using keyword queries and categorized them as “Patient Safety Errors” (e.g., ACP not in the centralized location)

Abstract Background and objective Several phase 2–4 studies have investigated mirabegron for treating patients with overactive bladder (OAB). The objective of this study was to evaluate the efficacy and safety of mirabegron in adult male OAB patients with or without benign prostate enlargement (BPE) receiving medications for lower urinary tract symptoms (LUTS) management. Methods A post hoc analysis of 13 phase 2–4 studies using mirabegron (2- or 4-wk single-blind placebo run

Abstract Gait is a complex, multifaceted process involving multiple organ systems. Both gait and transfer activities are key requirements for independent living. As individuals age, gait undergoes characteristic changes, including reduced walking speed, altered stride length, and increased variability. These changes are closely linked to the frailty syndromes of immobility, instability, cognitive impairment, incontinence, and iatrogenic harm. Alterations in gait and transfer

INTRODUCTION: Lower urinary tract symptoms (LUTS) are a common problem among older patients in primary and general care. OBJECTIVE: To estimate the prevalence of LUTS and their associates related to health, other geriatric problems, lifestyle, and social conditions in the Polish population of citizens aged over 60 years. PATIENTS AND METHODS: The analysis was part of a national cross-sectional study, PolSenior2, conducted in 2018-2019 on a cohort of 5698 community-dwelling

As palliative care physicians, we frequently refer patients to hospice care. When we do so, we often worry about them. How will they and their families manage custodial care—the day in, day out, physical and financial demands of caregiving—on top of navigating the inherent challenges of end of life? We know that high-quality hospice agencies provide patients and their families with invaluable support for symptomatic, emotional, and spiritual needs. But in the US, due to const

Abstract Introduction: Residents who use multifunctional wheelchairs before nursing home admission often face discontinuation of such devices after nursing home admission. However, basic data on this issue remain limited. Therefore, in this study, we aimed to provide preliminary data by investigating the occurrence of fall-related fractures after nursing home admission, stratified by the type of wheelchair used before nursing home admission. Methods: We used linked long-ter

Abstract Importance Hospitals have reported growing difficulty in discharging patients in a timely manner, often citing bottlenecks in postacute care. Medicare Advantage plans, now the dominant form of Medicare coverage, may contribute to these delays due to administrative and network constraints, yet national evidence is lacking. Objective To quantify changes in hospital length of stay for Medicare Advantage vs traditional Medicare beneficiaries. Design, Setting, and Par

Abstract Objectives To assess whether innovation in medical procedures and products—proxied by the expansion of Healthcare Common Procedure Coding System (HCPCS) codes linked to Medicare Coverage Determinations (MCDs)—is associated with declines in disability among U.S. adults from 1997 to 2019. Methods We link HCPCS codes to ICD condition categories using Local Coverage Determinations (LCD) and merge these with Medical Expenditure Panel Survey (MEPS) data to construct 21 con

A recent study published in the Annals of Internal Medicine reveals a growing crisis in U.S. healthcare: nearly 5% of physicians left clinical practice in 2019—a 40% increase in just six years. Burnout, bureaucracy, and declining reimbursements are pushing doctors out of medicine. For every hour spent with patients, physicians spend nearly two on documentation, leaving little time for family or rest. Fear of malpractice lawsuits further fuels “defensive medicine,” where unne

A major European study published in the New England Journal of Medicine suggests that prostate cancer screening can reduce deaths by 13%, strengthening the case for a UK screening program. The research, involving 162,000 men across eight countries over 23 years, found that one prostate cancer death was prevented for every 456 men invited for screening and for every 12 diagnosed cases. Experts say the results are comparable to those from breast and bowel cancer screening prog

New research presented at IDWeek 2025 revealed that deaths from Clostridioides difficile infection (CDI) are significantly more common among White Americans and people living in large urban areas. Between 1999 and 2023, 83.9% of the 216,311 CDI-related deaths in the United States occurred in White individuals, compared with 8.1% in Black and 5.5% in Hispanic populations—despite their smaller share of the population. Researchers found that 83.8% of deaths were in metropolitan

Abstract Objectives Sacral neuromodulator implantation (SNM) is an advanced line of treatment for patients with overactive bladder (OAB) or underactive bladder (UAB). The procedure has two steps; patients who respond to temporary SNM proceed to permanent implantation. In this study, we aimed to evaluate the overall effectiveness of SNM in our patient population, as well as to identify potential correlations between patient demographics, clinical characteristics, and procedura